INFLUENCE OF DIAZEPAM ON THE PHARMACOKINETIC PROPERTIES OF ORALLY-ADMINISTERED NAPROXEN

被引：0
|
作者：
RAO, BR [1 ]
RAMBHAU, D [1 ]
机构：
[1] KAKATIYA UNIV,FAC PHARMACEUT SCI,UNIV COLL PHARMACEUT SCI,WARANGAL 506009,ANDHRA PRADESH,INDIA
来源：
DRUG INVESTIGATION | 1992年 / 4卷 / 05期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of a single dose of diazepam on the pharmacokinetics of naproxen was studied in 10 healthy subjects by administering in a crossover design single doses of naproxen 500mg alone or in combination with 10mg of diazepam. Mean peak serum naproxen concentrations were lowered (83.4 to 64.5 mg/L), the time to peak concentration was increased (1.36 to 2.0h) and the absorption rate was decreased (4.07 to 2.42h-1) when naproxen was administered with diazepam. However, none of the other pharmacokinetic parameters of the drug were significantly altered in the presence of diazepam.
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页码：416 / 421
页数：6
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