HUMAN ALPHA-B-CRYSTALLIN (CRYA2) GENE MAPPED TO CHROMOSOME 11Q12-Q23

被引：23
|
作者：
BRAKENHOFF, RH
VANKESSEL, AHMG
OLDENBURG, M
WIJNEN, JT
BLOEMENDAL, H
KHAN, PM
SCHOENMAKERS, JGG
机构：
[1] CATHOLIC UNIV NIJMEGEN,DEPT MOLEC BIOL & CELL BIOL,6525 ED NIJMEGEN,NETHERLANDS
[2] CATHOLIC UNIV NIJMEGEN,DEPT HUMAN GENET,6500 HB NIJMEGEN,NETHERLANDS
[3] CATHOLIC UNIV NIJMEGEN,DEPT BIOCHEM,6500 HB NIJMEGEN,NETHERLANDS
[4] LEIDEN STATE UNIV,SYLVIUS LAB,INST HUMAN GENET,2312 AV LEIDEN,NETHERLANDS
来源：
HUMAN GENETICS | 1990年 / 85卷 / 02期
关键词：
D O I：
10.1007/BF00193203
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The αB-crystallin gene (CRYA2) encodes the abundant lens protein αB-crystallin. A panel of human/ rodent hybrid cell lines, derived from five different parental combinations, was characterized with respect to human chromosomal content and the presence of well-established human chromosome-specific markers. This panel was screened for the presence of CRYA2, using the third exon of the hamster αB-crystallin gene as a probe. The patterns of segregation of CRYA2 with individual human chromosomes show the highest degree of concordance between CRYA2 and chromosome 11. Using cell hybrids containing translocated and/or partially deleted human chromosomes, the CRYA2 gene was localized to 11q12-11q23. © 1990 Springer-Verlag.
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收藏
页码：237 / 240
页数：4
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