Localization of the Gene Encoding Human Factor V to Chromosome 1q21-25

被引：34
|
作者：
Wang, H. [1 ]
Riddell, D. C. [1 ]
Guinto, E. R. [2 ]
MacGillivray, R. T. A. [2 ]
Hamerton, J. L. [1 ]
机构：
[1] Univ Manitoba, Dept Human Genet, Winnipeg, MB R3E 0W3, Canada
[2] Univ British Columbia, Dept Biochem, Vancouver, BC V6T 1W5, Canada
来源：
GENOMICS | 1988年 / 2卷 / 04期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/0888-7543(88)90021-3
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The gene encoding human coagulation Factor V (FV), one of the cofactors in the blood clotting process, has been mapped to chromosome 1 by both Southern hybridization to DNA from human-hamster somatic cell hybrids and in situ hybridization. The whole plasmid pUC3A containing a 1.5-kb cDNA sequence for FV was P-32-labeled for Southern analysis and H-3-labeled for in situ hybridization to metaphase chromosomes. The results localized the FV gene to the region of 1q21-25. (C) 1988 Academic Press, Inc.
引用
收藏
页码：324 / 328
页数：5
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