MAPPING OF THE HUMAN NMDAR2B RECEPTOR SUBUNIT GENE (GRIN2B) TO CHROMOSOME 12P12

被引：22

作者：

MANDICH, P ^{[1
]}

SCHITO, AM ^{[1
]}

BELLONE, E ^{[1
]}

ANTONACCI, R ^{[1
]}

FINELLI, P ^{[1
]}

ROCCHI, M ^{[1
]}

AJMAR, F ^{[1
]}

机构：

[1] UNIV BARI,INST GENET,I-70126 BARI,ITALY

来源：

GENOMICS | 1994年 / 22卷 / 01期

关键词：

D O I：

10.1006/geno.1994.1366

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The N-methyl-D-aspartate (NMDA) receptor channel is essential for synaptic transmission and synaptic plasticity underlying memory, learning, and development. Three subunits of the NMDA receptor channel, NMDAR2A, NMDAR2B, and NMDAR2C (NR2A, NR2B, and NR2C), previously identified in mouse by cDNA cloning and expression, share a high level of homology, although their patterns of expression within the brain may differ. In the present work we report the localization of the gene encoding the human NMDAR2B receptor subunit (called GRIN2B for glutamate receptor, ionotropic, N-methyl-D-aspartate 2B) to chromosome 12p12 by in situ hybridization and somatic cell hybrids. (C) 1994 Academic Press, Inc.

引用

页码：216 / 218

页数：3

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