NOVEL SPONGE-DERIVED AMINO-ACIDS .14. NEW STRUCTURES AND BIOACTIVITY PATTERNS OF BENGAZOLE ALKALOIDS FROM A CHORISTID MARINE SPONGE

New bengazoles 3-9 as inseparable mixtures are reported from the sponge Jaspis cf. coricea collected in Papua New Guinea, These compounds contain a new variation of the unusual bisoxazole core present in bengazole A [1]. The B-ring oxazole hexatetraol side chain is varyingly substituted with either myristic acid or 13-methylmyristic acid. Hydrolysis of three different bengazole mixtures each yielded an identical tetraol, bengazole Z [11].