EFFECT OF RU-38486 ON DEXAMETHASONE REVERSAL OF MORPHINE-INDUCED CONSTIPATION IN MICE

被引：6
|
作者：
PERSICO, P
CAPASSO, A
CALIGNANO, A
SORRENTINO, L
机构：
[1] Department of Experimental Pharmacology, University of Naples Federico II, 80131 Naples, Via Domenico Montesano
来源：
GENERAL PHARMACOLOGY | 1991年 / 22卷 / 05期
关键词：
D O I：
10.1016/0306-3623(91)90221-Q
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Morphine and dexamethasone significantly reduce gastrointestinal transit in mice. The degree of reduction was greater for morphine. 2. Dexamethasone pretreatment was found, however, to antagonize morphine-induced constipation. 3. Cycloheximide does not modify the dexamethasone effects. 4. RU-38486 reverses both the inhibitory action of dexamethasone on gastrointestinal transit and its reducing effect on morphine-induced constipation. 5. These results suggest that dexamethasone might act through binding to receptors not linked to DNA-responsive elements.
引用
收藏
页码：867 / 868
页数：2
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