Antimicrobial Efficacy of a New Chlorhexidine-based Device Against Staphylococcus aureus Colonization of Venous Catheters

被引：5
|
作者：
Kowalewska, Paulina M. [3 ]
Petrik, Shawn M. [4 ]
Di Fiore, Attilio E. [5 ]
Fox-Robichaud, Alison E. [1 ,2 ]
机构：
[1] McMaster Univ, Thrombosis & Atherosclerosis Res Inst, Hamilton, ON, Canada
[2] McMaster Univ, Dept Med, Hamilton, ON, Canada
[3] Univ Western Ontario, Dept Med Biophys, London, ON, Canada
[4] McMaster Univ, Thrombosis & Atherosclerosis Res Inst, Comparat Med, Hamilton, ON, Canada
[5] ATTWILL Med Solut Inc, W Jordan, UT USA
来源：
JOURNAL OF INFUSION NURSING | 2018年 / 41卷 / 02期
关键词：
antimicrobial devices; catheter-related infection; ChloraLock; chlorhexidine digluconate; swine model;
D O I：
10.1097/NAN.0000000000000267
中图分类号：
R47 [护理学];
学科分类号：
1011 ;
摘要：
Vascular catheters are a major cause of nosocomial bloodstream infections. ChloraLock (ATTWILL Medical Solutions, Inc, West Jordan, UT, and ICU Medical, Inc, San Clemente, CA) is a novel antimicrobial device containing chlorhexidine digluconate (CHG) that is fitted onto a syringe and infuses CHG into the catheter lumen during locking. The objective of this study was to evaluate the antimicrobial efficacy of ChloraLock with in vitro tests and its ability to reduce Staphylococcus aureus contamination of catheters in the external jugular veins of Yorkshire swine. ChloraLock significantly reduced the bacterial load in the in vitro tests by up to 6 log(10) colony-forming units (CFU) and by 3 to 4 log(10) CFU/lumen in vivo in a swine model with 0.9% NaCl catheter locks.
引用
收藏
页码：103 / 112
页数：10
相关论文
共 50 条
  • [1] Antimicrobial Efficacy of Herbal and Chlorhexidine Mouthrinse against Staphylococcus aureus - An in vitro Microbiological Study
    Nagappan, Nagappan
    Palaneeswaran, Kamalashankar
    Kumarappan, Kannan
    Natarajan, Raghunathan
    Tajuddin, Rameezuddin
    Anusha, Yalamanchi
    JOURNAL OF PHARMACY AND BIOALLIED SCIENCES, 2022, 14 : 318 - 322
  • [2] Use of antimicrobial dressing with chlorhexidine gluconate in infections by staphylococcus aureus in central venous catheters with continuous infusion of iloprost
    Carvalho, E.
    Sandra Mendes, S.
    Santos, M.
    EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING, 2012, 11 : S81 - S81
  • [3] Daily Bathing with Chlorhexidine-Based Soap and the Prevention of Staphylococcus aureus Transmission and Infection
    Viray, Melissa A.
    Morley, James C.
    Coopersmith, Craig M.
    Kollef, Marin H.
    Fraser, Victoria J.
    Warren, David K.
    INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2014, 35 (03): : 243 - 250
  • [4] Efficacy and Limitation of a Chlorhexidine-Based Decolonization Strategy in Preventing Transmission of Methicillin-Resistant Staphylococcus aureus in an Intensive Care Unit
    Batra, Rahul
    Cooper, Ben S.
    Whiteley, Craig
    Patel, Amita K.
    Wyncoll, Duncan
    Edgeworth, Jonathan D.
    CLINICAL INFECTIOUS DISEASES, 2010, 50 (02) : 210 - 217
  • [5] Frequent Use of Chlorhexidine-Based Body Wash Associated with a Reduction in Methicillin-Resistant Staphylococcus aureus Nasal Colonization among Military Trainees
    Millar, Eugene V.
    Chen, Wei-Ju
    Schlett, Carey D.
    Cui, Tianyuan
    Crawford, Katrina B.
    Lanier, Jeffrey B.
    Tribble, David R.
    Ellis, Michael W.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (02) : 943 - 949
  • [6] Efficacy and tolerability of a new chlorhexidine-based vaginal gel in vaginal infections
    Molteni, B
    D'Antuono, A
    Bandini, P
    Sintini, G
    Barcellona, E
    Agnello, A
    Milani, M
    CURRENT MEDICAL RESEARCH AND OPINION, 2004, 20 (06) : 849 - 853
  • [7] Central venous catheter colonization with Staphylococcus aureus is not always an indication for antimicrobial therapy
    Munoz, P.
    Fernandez Cruz, A.
    Usubillaga, R.
    Zorzano, A.
    Rodriguez-Creixems, M.
    Guembe, M.
    Bouza, E.
    CLINICAL MICROBIOLOGY AND INFECTION, 2012, 18 (09) : 877 - 882
  • [8] Chlorhexidine-based body washing for colonization and infection of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus: an updated meta-analysis
    Xiao, Guibao
    Chen, Zhu
    Lv, Xiaoju
    INFECTION AND DRUG RESISTANCE, 2018, 11 : 1473 - 1481
  • [9] New antimicrobial agents active against Staphylococcus aureus
    James S. Tan
    Current Infectious Disease Reports, 2005, 7 (5) : 357 - 358
  • [10] Efficacy of Cathelicidin-Mimetic Antimicrobial Peptoids against Staphylococcus aureus
    Benjamin, Aaron B.
    Moule, Madeleine G.
    Didwania, Maruti K.
    Hardy, Jonathan
    Saenkham-Huntsinger, Panatda
    Sule, Preeti
    Nielsen, Josefine Eilso
    Lin, Jennifer S.
    Contag, Christopher H.
    Barron, Annelise E.
    Cirillo, Jeffrey D.
    MICROBIOLOGY SPECTRUM, 2022, 10 (03):
12345