ENDOTHELIN INDUCES THROMBOXANE RELEASE AND CONTRACTION OF ISOLATED GUINEA-PIG AIRWAYS

被引：46
|
作者：
FILEP, JG
BATTISTINI, B
SIROIS, P
机构：
[1] Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, Sherbrooke
来源：
LIFE SCIENCES | 1990年 / 47卷 / 20期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/0024-3205(90)90287-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The possible role of thromboxane (TX) A2 in mediating the bronchopulmonary effect of endothelin (ET) was studied in isolated guinea pig airways (trachea, upper bronchi and parenchyma). ET (1-100 nM) evoked a concentration-dependent contraction of all three tissues. The contractile response was significantly attenuated by pretreatment of the tissues with the specific thromboxane receptor blockers, BM 13177 (10-50 μM) and BM 13505 (1-5 μM). Furthermore, ET caused a dose-dependent TXB2 release from trachea and parenchyma. These findings suggest that the bronchopulmonary action of ET is mediated, in part, by the release of TXA2. © 1990.
引用
收藏
页码：1845 / 1850
页数：6
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