BIOCHEMICAL BASIS OF RESISTANCE TO CHEMOTHERAPY

被引：13
|
作者：
MASTERS, JRW
机构：
[1] Institute of Urology, University College London, St. Pauls Hospital, London
来源：
RADIOTHERAPY AND ONCOLOGY | 1990年 / 19卷 / 04期
关键词：
CHEMOTHERAPY; MULTIDRUG RESISTANCE; P-GLYCOPROTEIN; GLUTATHIONE; TOPOISOMERASE-II;
D O I：
10.1016/0167-8140(90)90029-V
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent progress in the understanding of drug resistance has led to the discovery of new targets for chemotherapy. By attacking the molecules that make cancer cells insensitive to chemotherapy, it is hoped that drug-resistant disease will respond to treatment. This review describes some of the latest advances in understanding of the biochemistry of drug resistance. Following a general introduction four areas of topical interest are discussed: (1) multidrug resistance and P-glycoprotein, (2) glutathione and its related enzymes, (3) topoisomerase II and (4) DNA repair.
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页码：297 / 305
页数：9
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