SYNCHRONIZED RETROPERFUSION COMBINED WITH CORONARY SINUS OCCLUSION - EXPERIMENTAL MEASUREMENTS COMPARED WITH SIMULATION RESULTS AND MODEL PREDICTIONS

A mathematical model has been developed to investigate the hemodynamic effects of different modes of coronary sinus interventions. To compare the predictions of this model with experimentally derived results, six open chested dogs with coronary artery occlusions were studied. Aortic pressure, coronary venous pressure, and LAD pressure distal to the occlusion were measured. Throughout each experiment, retroperfusion of arterial blood into the coronary sinus, synchronized to diastole (SRP), was performed at flow rates of 25, 50, 75, and 100 ml/min. In each dog, two modes of superimposed coronary sinus occlusion were investigated: mode 1, the coronary sinus was occluded only during diastole; mode 2, coronary sinus occlusion was extended until coronary sinus pressure reached a plateau. The validity of themodel was confirmed by a satisfactory agreement between the experimentally and mathematically derived. © 1990 Taylor & Francis Group, LLC.