EARLY CARDIAC TOXICITY OF 4'-IODO-4'-DEOXYDOXORUBICIN

被引：9
|
作者：
VILLANI, F
GALIMBERTI, M
COMAZZI, R
机构：
[1] Divisione di Fisiopatologia Cardiorespiratoria, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan
来源：
EUROPEAN JOURNAL OF CANCER | 1991年 / 27卷 / 12期
关键词：
D O I：
10.1016/0277-5379(91)90423-B
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
4'-iodo-4'-deoxydoxorubicin was administered intravenously to 35 patients with advanced malignant neoplasms. The doses were escalated as follows: 2, 4, 6, 7, 10, 14, 19, 26, 52, 70, 80 and 90 mg/m2. Myocardial function was assessed by Holter monitoring and echocardiography. The prevalence of arrhythmias that could be attributed to the drug in the 24 h following infusion was 14.3% (supraventricular) and 10.6% (ventricular). Echocardiographic heart function variables were unchanged at 24 h and 21 days from drug injection. The data indicate the absence of significant, acute cardiotoxic effects of 4'-iodo-4'-deoxydoxorubicin.
引用
收藏
页码：1601 / 1604
页数：4
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