SYNTHESIS OF 1-PALMITOYL-2-HEXADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE (PHPC)

被引：8
|
作者：
DUCLOS, RI
机构：
[1] Biophysics Department, Housman Medical Research Center, Boston University School of Medicine, Boston, MA 02118-2394
来源：
CHEMISTRY AND PHYSICS OF LIPIDS | 1993年 / 66卷 / 03期
关键词：
1-ACYL-2-ALKYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1-PALMITOYL-2-HEXADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE; PHPC; 1-ACETYL-2-HEXADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE; AHPC; PALMITIC ANHYDRIDE;
D O I：
10.1016/0009-3084(93)90001-J
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A general method for the chirospecific synthesis of 1-acyl-2-alkyl-sn-glycero-3-phosphocholines is described. 1-Palmitoyl-2-hexadecyl-sn-glycero-3-phosphocholine (PHPC) was synthesized in 18% overall yield in ten steps via five new synthetic intermediates, and 1-acetyl-2-hexadecyl-sn-glycero-3-phosphocholine (AHPC) was also synthesized. 1-Acyl-2-alkyl-sn-glycero-3-phosphocholine which have not been found to exist in nature, are ether lipid analogs of 1,2-diacyl-sn-glycero-3-phosphocholines, which are important components of cell membranes. Biophysical studies of hydrated bilayers of PHPC will be of interest in probing the critical importance of the central region of these amphiphilic molecules to the molecular assemblies that are formed.
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页码：161 / 170
页数：10
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