SESQUITERPENE LACTONES AND OTHER CONSTITUENTS FROM A CYTOTOXIC EXTRACT OF MICHELIA-FLORIBUNDA

被引：18
|
作者：
MONDRANONDRA, IO
CHE, CT
RIMANDO, AM
VAJRODAYA, S
FONG, HHS
FARNSWORTH, NR
机构：
[1] UNIV ILLINOIS,COLL PHARM,PHARMACEUT SCI,PROGRAM COLLABORAT RES,POB 6998,CHICAGO,IL 60680
[2] CHULALONGKORN UNIV,FAC PHARMACEUT SCI,DEPT PHARMACEUT BOT,BANGKOK 5,THAILAND
来源：
PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 12期
关键词：
cytotoxicity test; dihydroreynosin glucoside; dihydrotamaulipin A glucoside; isolation; Magnoliaceae; Michelia floribunda; sesquiterpene lactones;
D O I：
10.1023/A:1015937921880
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The pentane and CHC13 fractions of a crude extract of Michelia floribunda exhibited cytotoxic activity when tested in KB and P388 tumor cell cultures. Repeated chromatography led to the isolation of three cytotoxic sesquiterpene lactones (costunolide, parthenolide, and santamarine) and a cytotoxic isoquinoline alkaloid (liriodenine). Inactive sesquiterpene lactones obtained during the course of this study included dihydroparthenolide and two new glucosides of dihydrotamaulipin A and dihydroreynosin (1 and 2). The structures of these new compounds were determined through interpretation of their spectroscopic data including 2D-NMR spectroscopy. Syringin was also isolated from the extract. © 1990, Plenum Publishing Corporation. All rights reserved.
引用
收藏
页码：1269 / 1272
页数：4
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