POTASSIUM CURRENTS ACTIVATED IN HIPPOCAMPAL-NEURONS BY SEROTONIN ARE MEDIATED BY A CHANGE IN INTRACELLULAR CALCIUM CONCENTRATIONS

被引：13
|
作者：
SEGAL, M
机构：
[1] Center for Neurosciences, The Weizmann Institute of Science, Rehovot
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 181卷 / 03期
关键词：
5-HT; (5-hydroxytryptamine; serotonin); BAPTA (1,2-bis(oaminophenoxy)ethane-N,N,N,N-tetraacetic acid; Ca[!sup]2+[!/sup; Hippocampal slices;
D O I：
10.1016/0014-2999(90)90093-L
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Intracellular activity was recorded from CA1 neurons in the slice preparation, by using K-acetate-, Bapta- or EGTA-filled micropipettes. The calcium chelator, Bapta, clamps [Ca]i more rapidly than EGTA and is less associated with pH changes. Neurons recorded with Bapta-filled micropipettes were much less sensitive to 5-HT and baclafen than those recorded with the standard K-acetate- or EGTA-filled micropipetes. These results suggest that [Ca]i is important for the generation of the 5-HT-dependent potassium current. © 1990.
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页码：299 / 301
页数：3
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