EFFECTS OF SOME ADENOSINE-ANALOGS ON MORPHINE-INDUCED ANALGESIA AND TOLERANCE

被引：29
|
作者：
CONTRERAS, E
GERMANY, A
VILLAR, M
机构：
[1] Farmacologia, Departamento de Ciencias Fisiológicas, Facultad de Ciencias Biológicas y de Recursos Naturales, Concepción
来源：
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1990年 / 21卷 / 05期
关键词：
D O I：
10.1016/0306-3623(90)91031-L
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The analogs of adenosine d- and l-phenylisopropyladenosine (d- and l-PIA) and chloroadenosine (CADO) induced analgesia in mice (hot-plate test). 2. The antinociceptive effects of the three adenosine agonists were antagonized by caffeine but were unaffected by naloxone. 3. Morphine-induced antinociception was increased by pretreatment with adenosine agonists. 4. Whereas CADO significantly attenuated the induction of morphine tolerance, d- and l-PIA did not affect the process. © 1990.
引用
收藏
页码：763 / 767
页数：5
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