SYNTHETIC PEPTIDES COMPRISING DEFINED SEQUENCES OF CH-2 AND CH-3 DOMAINS OF HUMAN IGG1 INDUCE PROSTAGLANDIN-E2 PRODUCTION FROM HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS

被引：0
|
作者：
KADAR, J [1 ]
KALMAR, L [1 ]
STANWORTH, DR [1 ]
GERGELY, P [1 ]
机构：
[1] UNIV BIRMINGHAM,DEPT IMMUNOL,RHEUMATOL & ALLERGY RES UNIT,BIRMINGHAM B15 2TJ,W MIDLANDS,ENGLAND
来源：
IMMUNOLOGY LETTERS | 1992年 / 32卷 / 01期
关键词：
SYNTHETIC PEPTIDE; PROSTAGLANDIN E2 PRODUCTION; LEUKOCYTE MIGRATION INHIBITORY FACTOR (LMIF);
D O I：
10.1016/0165-2478(92)90199-X
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Synthetic peptides Y48 and Y75 comprising sequences at exposed sites within the CH-2 and CH-3 domains of human IgG1 at a concentration of 10(-5) M, increase PGE2 production by human peripheral blood mononuclear cell (PBMC) cultures. An increase of leukocyte migration inhibitory factor (LMIF) production in PBMC cultures - as a result of synthetic peptide treatment - was also observed. This LMIF activity, to some extent, is attributed to the PGE2 production by the cells; the inhibition of leukocyte migration being abolished by the presence of indomethacine or antibody to PGE2.
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页码：59 / 64
页数：6
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