PASSIVE SMOKING IS ASSOCIATED WITH AN INCREASED RISK OF DEVELOPING INFLAMMATORY BOWEL-DISEASE IN CHILDREN

被引:0
|
作者
LASHNER, BA [1 ]
SHAHEEN, NJ [1 ]
HANAUER, SB [1 ]
KIRSCHNER, BS [1 ]
机构
[1] UNIV CHICAGO,MED CTR,DEPT PEDIAT,GASTROENTEROL SECT,CHICAGO,IL 60637
来源
AMERICAN JOURNAL OF GASTROENTEROLOGY | 1993年 / 88卷 / 03期
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Adult cigarette smoking is associated with the development of Crohn's disease and protection from the development of ulcerative colitis. Children usually are nonsmokers whose risk of developing inflammatory bowel disease (IBD) may be related to passive smoking. The purpose of this matched case-control study was to evaluate passive smoking exposure in 72 nonsmoking children with recently diagnosed IBD (39 with ulcerative colitis and 33 with Crohn's disease), and in an equal number of peer-nominated controls. Passive smoking exposure at birth was significantly associated with the development of IBD (odds ratio 3.02, 95% confidence interval 1.28-7.06). The effect was greater in Crohn's disease (odds ratio 5.32) than in ulcerative colitis (odds ratio 2.19). Maternal smoking at birth also was significantly associated with the development of IBD (odds ratio 2.09,95% confidence interval 1.02-4.29), an effect that also was greater in Crohn's disease than in ulcerative colitis. There was a dose-response relationship between packs smoked per day and IBD, and packs smoked at home per day and IBD. At symptom onset, the risk of developing IBD from passive smoking exposure was increased but was not significant (odds ratio 1.88, 95% confidence interval 0.84-4.18). The magnitude of the effect was greater in Crohn's disease than in ulcerative colitis, and the association demonstrated dose-response. In conclusion, passive smoking exposure and maternal smoking at birth and, to a lesser extent, passive smoking exposure at symptom onset are associated with an increased risk of developing IBD in children. The association is stronger in Crohn's disease than in ulcerative colitis, and there is a dose-response effect. The specific toxic exposure is more likely to be inhaled rather than passed through the placenta or in breast milk.
引用
收藏
页码:356 / 359
页数:4
相关论文
共 50 条
  • [1] ARE NURSES AT AN INCREASED RISK OF DEVELOPING INFLAMMATORY BOWEL-DISEASE
    MAYBERRY, JF
    NEWCOMBE, RG
    [J]. DIGESTION, 1981, 22 (03) : 150 - 154
  • [2] SMOKING AND INFLAMMATORY BOWEL-DISEASE
    LOGAN, RFA
    KATCHINSKI, B
    SOMERVILLE, KW
    PEARSON, JCG
    LANGMAN, MJS
    [J]. GASTROENTEROLOGY, 1986, 90 (05) : 1525 - 1525
  • [3] SMOKING AND INFLAMMATORY BOWEL-DISEASE
    LINDBERG, E
    TYSK, C
    JARNEROT, G
    ANDERSSON, K
    [J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1986, 21 : 5 - 5
  • [4] SMOKING AND INFLAMMATORY BOWEL-DISEASE
    TOBIN, MV
    LOGAN, RFA
    LANGMAN, MJS
    MCCONNELL, RB
    GILMORE, IT
    [J]. GUT, 1985, 26 (10) : 1155 - 1155
  • [5] SMOKING AND INFLAMMATORY BOWEL-DISEASE
    KATSCHINSKI, B
    LOGAN, RFA
    LANGMAN, MJS
    [J]. ZEITSCHRIFT FUR GASTROENTEROLOGIE, 1989, 27 (10): : 614 - 618
  • [6] SMOKING AND INFLAMMATORY BOWEL-DISEASE
    RICCI, R
    DIPAOLO, MC
    RICCI, F
    PALLONE, F
    PAOLUZI, P
    [J]. ITALIAN JOURNAL OF GASTROENTEROLOGY, 1986, 18 (04): : 209 - 210
  • [7] ARTHRITIS ASSOCIATED WITH INFLAMMATORY BOWEL-DISEASE IN CHILDREN
    LINDSLEY, CB
    SCHALLER, JG
    [J]. JOURNAL OF PEDIATRICS, 1974, 84 (01): : 16 - 20
  • [8] INCREASED RISK OF INFLAMMATORY BOWEL-DISEASE ASSOCIATED WITH ORAL-CONTRACEPTIVE USE
    BOYKO, EJ
    THEIS, MK
    VAUGHAN, TL
    NICOLBLADES, B
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1994, 140 (03) : 268 - 278
  • [9] SMOKING, SUGAR, AND INFLAMMATORY BOWEL-DISEASE
    THORNTON, JR
    EMMETT, PM
    HEATON, KW
    [J]. BRITISH MEDICAL JOURNAL, 1985, 290 (6484): : 1786 - 1787
  • [10] ARTHRITIS ASSOCIATED WITH INFLAMMATORY BOWEL-DISEASE IN CHILDREN - RELATIONSHIP BETWEEN ARTHRITIS AND ACTIVITY OF THE INFLAMMATORY BOWEL-DISEASE
    PASSO, M
    BRANDT, K
    FITZGERALD, J
    [J]. ARTHRITIS AND RHEUMATISM, 1979, 22 (06): : 645 - 645