SUSTAINED-RELEASE OF 5-FLUOROURACIL FROM OIL/WATER EMULSIONS

被引：0
|
作者：
ISHIKAWA, M [1 ]
KIKUTA, H [1 ]
IMAIZUMI, A [1 ]
SUZUKI, EI [1 ]
TAKAYANAGI, Y [1 ]
SASAKI, KI [1 ]
机构：
[1] TOHOKU ROSAI HOSP,DEPT PHARM,AOBA KU,SENDAI 981,JAPAN
来源：
RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY | 1992年 / 76卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Release profile of 5-fluorouracil (5-FU) from O/W emulsion and bone marrow toxicity of 5-FU to mice were compared with those of an aqueous solution of 5-FU. 5-FU emulsion had lower bone marrow toxicity and a slower drug release rate than the 5-FU aqueous solution which exhibited high bone marrow toxicity and fast drug release rate. A correlation between the rate of drug release and bone marrow toxicity was suggested.
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页码：245 / 248
页数：4
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