SURFACTANT IMPROVES LUNG-FUNCTION AND MORPHOLOGY IN NEWBORN RABBITS WITH MECONIUM ASPIRATION

被引:0
|
作者
SUN, B
CURSTEDT, T
SONG, GW
ROBERTSON, B
机构
[1] ST GORANS UNIV HOSP,EXPTL PERINATAL PATHOL RES UNIT,BOX 12500,S-11281 STOCKHOLM,SWEDEN
[2] DANDERYD HOSP,DEPT CLIN CHEM,S-18288 DANDERYD,SWEDEN
来源
BIOLOGY OF THE NEONATE | 1993年 / 63卷 / 02期
关键词
MECONIUM ASPIRATION; PULMONARY SURFACTANTS; ANIMALS; NEWBORN; LUNG COMPLIANCE;
D O I
暂无
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Nearly mature newborn rabbits (gestational age 29.5 days) were tracheotomized at birth and received, via the tracheal cannula, 6 ml/kg body weight of a filtered saline suspension of human meconium, 65 or 130 mg/ml. Animals were kept in body plethysmographs and ventilated for 60 min with standardized tidal volume (8-10 ml/kg). Aspiration of meconium caused, in both groups, a statistically significant reduction in lung-thorax compliance, elevated PCO2 in heart blood and reduced alveolar volume density (V(V)) in histological sections. Both groups responded to treatment with exogenous surfactant (Curosurf, 200 mg/kg) with a moderate, statistically significant improvement in lung-thorax compliance, PCO2 and alveolar V(V). Our data indicate that respiratory failure after neonatal meconium aspiration may be influenced favorably by treatment with exogenous surfactant.
引用
收藏
页码:96 / 104
页数:9
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