The study examined how particular demographic and multicultural personality variables might predict university adjustment of international students in Turkey. One hundred and twenty-one international students from five geographical regions, including Middle Central Asia, the Balkans, the Middle East, the Kafkasia Region, and the Russian Federations, studying in a main university in Izmir, Turkey, participated in the study. The Multicultural Personality Questionnaire (Van der Zee and Van Oudenhoven, 2000) and a demographic information questionnaire were used to collect data, which were examined in regard to responses to the University Life Scale (Aladag, Kagnici, Tuna and Tezer, 2003). According to the results, while demographic variables did not significantly predict the university adjustment of international students, multicultural personality variables did. Social initiative, emotional stability, open-mindedness and cultural empathy were found to be significant predictors of university adjustment.