According to some researchers, in recent years there has been an upward trend in predominant stagnating regions in Russia. The reasons for this include low innovation activity of the periphery, deindustrialization, predominant extractive industries, capital exports, growing social and property stratification and other equally important reasons. The current economic and political crisis in our country is both a threat, an opportunity and an impetus to restructuring the regional economy. In these conditions it becomes extremely necessary to search for new growth points in the regional economy, support for the most promising industries, and efficient resource allocation. Inter-regional cooperation is the most important area of the regional policy, ensuring progressive balanced socio-economic development of regions based on establishing long-term, equal and mutually beneficial relations between them. The importance of inter-regional cooperation for the development of modern Russia's constituent entities is determined by the fact that it strengthens economic ties between them, optimizes the location of infrastructure facilities based on cooperation of their activities, eliminates inefficient financial costs associated with the creation of duplicate economic structures in Russia's constituent entities and unjustified inter-regional competition, combines the regions' economic potential for implementing the most large-scale investment projects, spreads innovative experience in innovation development. The implementation of these measures is complicated by lack of sound socio-economic regional public policy. In this regard, problems such as systematization of best domestic and foreign practices in interregional cooperation, research and generalization of theoretical concepts presented in domestic and foreign publications, and development of an organizational and economic mechanism of managing inter-regional cooperation and methodological aspects for evaluating the efficiency of this process become relevant. The developed proposals can be used by public administration entities to improve the efficiency of applying the interregional cooperation factor as a driver of regional economic growth in the development of legal, strategic and program-planning documents at the regional level.
