Potential Role of microRNAs in Cardiovascular Disease: Are They up to Their Hype?

被引：13
|
作者：
Duggal, Bhanu [1 ,2 ,3 ]
Gupta, Manveen K. [1 ]
Prasad, Sathyamangla V. Naga [1 ]
机构：
[1] Cleveland Clin, Lerner Res Inst, Dept Mol Cardiol, Cleveland, OH 44195 USA
[2] Grant Med Coll, Dept Cardiol, 4th Floor,Main Bldg, Bombay 400008, Maharashtra, India
[3] Sir JJ Grp Hosp, 4th Floor,Main Bldg, Bombay 400008, Maharashtra, India
来源：
CURRENT CARDIOLOGY REVIEWS | 2016年 / 12卷 / 04期
基金：
英国惠康基金;
关键词：
Cardiovascular disease; diagnostic biomarkers; miRNAs;
D O I：
10.2174/1573403X12666160301120642
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Purpose of Review: Cardiovascular diseases remain the foremost cause of mortality globally. As molecular medicine unravels the alterations in genomic expression and regulation of the underlying atherosclerotic process, it opens new vistas for discovering novel diagnostic biomarkers and therapeutics for limiting the disease process. miRNAs have emerged as powerful regulators of protein translation by regulating gene expression at the post-transcriptional level. Recent Findings: Overexpression and under-expression of specific miRNAs are being evaluated as a novel approach to diagnosis and treatment of cardiovascular disease. This review sheds light on the current knowledge of the miRNA evaluated in cardiovascular disease. Conclusion: In this review we summarize the data, including the more recent data, regarding miRNAs in cardiovascular disease and their potential role in future in diagnostic and therapeutic strategies.
引用
收藏
页码：304 / 310
页数：7
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