PHARMACOLOGICAL ACTIONS OF CENTRAL-NERVOUS-SYSTEM DEPRESSANTS GIVEN INTRAVENOUSLY AS SUSPENSIONS

被引：1
|
作者：
STUMPF, C [1 ]
VIERNSTEIN, H [1 ]
机构：
[1] UNIV VIENNA,INST PHARMACEUT TECHNOL,A-1090 VIENNA,AUSTRIA
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 1990年 / 79卷 / 12期
关键词：
D O I：
10.1002/jps.2600791205
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Three central nervous system (CNS) depressants, methohexital (sodium), midazolam (maleate), and flunitrazepam, were given intravenously to rabbits in equimolar doses as suspensions and solutions. The mean diameters of the particles in the suspensions were 770, 840, and 460 nm, respectively. The CNS actions were verified by recording the bioelectrical activity of the precentral cortex. The suspensions were tolerated well. There were no differences in onset, duration, and maximal intensity of action between suspension and solution of each drug. The results of this study should facilitate pharmacological studies of drugs acting on the CNS that are insoluble in water. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
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收藏
页码：1062 / 1064
页数：3
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