IN-VITRO ACTIVITIES OF FUROQUINOLINE AND ACRIDONE ALKALOIDS AGAINST PLASMODIUM-FALCIPARUM

被引：116
|
作者：
BASCO, LK
MITAKU, S
SKALTSOUNIS, AL
RAVELOMANANTSOA, N
TILLEQUIN, F
KOCH, M
LEBRAS, J
机构：
[1] UNIV PARIS 05,FAC PHARM,PHARMACOGNOSIE LAB,CNRS,URA 1310,F-75270 PARIS,FRANCE
[2] ECOLE NATL SUPER CHIM TOULOUSE,FIBRES ENERGIE BIOMONOMERES LAB,F-31078 TOULOUSE,FRANCE
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 05期
关键词：
D O I：
10.1128/AAC.38.5.1169
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The in vitro activities of furo[2,3b]quinoline and acridone alkaloids against Plasmodium falciparum were evaluated by an isotopic semimicrotest. A pyran ring in the furoquinoline nucleus and 2-O-pyranoglycoside and 2-nitro substituents in the acridone nucleus improved the antimalarial activities of the compounds. These findings provide a clue for further chemical modifications.
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页码：1169 / 1171
页数：3
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