NAD(P)H-NAD(P)+ MODELS .74. ENTROPY-CONTROLLED KINETICS, STEREOCHEMISTRY, AND TUNNELING EFFECT

被引：19
|
作者：
OHNO, A
GOTO, M
MIKATA, Y
KASHIWAGI, T
MARUYAMA, T
机构：
[1] Institute for Chemical Research, Kyoto University, Uji, Kyoto
来源：
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1991年 / 64卷 / 01期
关键词：
D O I：
10.1246/bcsj.64.87
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Kinetics have been studied for the reactions of three NAD(P)H analogs and their 4-deuteriated compounds with 2,6-dichloro- and tetrachloro-1,4-benzoquinones. It has been elucidated that the entropy term occupies 50-90% of the Gibbs energy of activation at 298 K. Thus, the reaction is almost entropy-controlled. For certain combinations of the reducing and oxidizing reagents, quantum mechanical tunneling effect plays a large role to determine the reaction rate. The tunneling effect may be another measure of the sterochemistry.
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页码：87 / 90
页数：4
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