INHIBITION OF SOLUBLE CATECHOL-O-METHYLTRANSFERASE AND SINGLE-DOSE PHARMACOKINETICS AFTER ORAL AND INTRAVENOUS ADMINISTRATION OF ENTACAPONE

被引：3

作者：

KERANEN, T

GORDIN, A

KARLSSON, M

KORPELA, K

PENTIKAINEN, PJ

RITA, H

SCHULTZ, E

SEPPALA, L

WIKBERG, T

机构：

[1] TAMPERE UNIV HOSP,DEPT NEUROL,TAMPERE,FINLAND

[2] ORION FARMOS PHARMACEUT,ORION RES CTR,ESPOO,FINLAND

[3] HELSINKI UNIV,DEPT MED 3,HELSINKI,FINLAND

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1994年 / 46卷 / 02期

关键词：

ENTACAPONE; CATECHOL-O-METHYLTRANSFERASE; PHARMACOKINETICS; HEALTHY VOLUNTEERS; ADVERSE EFFECTS; METABOLISM;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The inhibition of soluble catechol-O-methyl-transferase (S-COMT) in red blood cells (RB Cs) by entacapone, and the pharmacokinetics of entacapone after single oral (5-800 mg) and IV (25 mg) doses have been examined in an open study in 12 healthy young male volunteers.

引用

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页码：151 / 157

页数：7

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