OMEGA-CONOTOXIN GVIA BINDS TO AND BLOCKS RAT NEUROMUSCULAR-JUNCTION

被引：19
|
作者：
ROSSONI, G
BERTI, F
LAMAESTRA, L
CLEMENTI, F
机构：
[1] UNIV MILAN,DEPT PHARMACOL,I-20129 MILAN,ITALY
[2] UNIV MILAN,CNR,CTR CYTOPHARMACOL,I-20129 MILAN,ITALY
来源：
NEUROSCIENCE LETTERS | 1994年 / 176卷 / 02期
关键词：
OMEGA-CONOTOXIN; RAT NEUROMUSCULAR JUNCTION; N-TYPE CALCIUM CHANNEL; NICOTINIC RECEPTOR; AUTORADIOGRAPHY; ALPHA-BUNGAROTOXIN;
D O I：
10.1016/0304-3940(94)90078-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of omega-conotoxin GVIA, a specific blocker of N-type calcium channels, on the synaptic transmission at the mammalian neuromuscular junction is controversial. We have found that I-125-omega-conotoxin binds to rat tibialis muscle end-plate; that omega-conotoxin blocks the neuromuscular transmission both in vivo, in the sciatic nerve-tibialis anterior muscle, and in vitro in the isolated phrenic nerve-diaphragm preparation; and does not affect muscle nicotinic receptors. We conclude that in rat neuromuscular junctions N-type calcium channels are important for neurotransmitter secretion.
引用
收藏
页码：185 / 188
页数：4
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