STRUCTURE-RELATED INHIBITING ACTIVITY OF SOME TOBACCO CEMBRANOIDS ON THE PROSTAGLANDIN SYNTHESIS IN-VITRO

被引：24
|
作者：
OLSSON, E
HOLTH, A
KUMLIN, E
BOHLIN, L
WAHLBERG, I
机构：
[1] RESERCA AB,S-11884 STOCKHOLM,SWEDEN
[2] UNIV UPPSALA,CTR BIOMED,DEPT PHARMACOGNOSY,S-75123 UPPSALA,SWEDEN
来源：
PLANTA MEDICA | 1993年 / 59卷 / 04期
关键词：
NICOTIANA-TABACUM; CEMBRANOIDS; PROSTAGLANDIN SYNTHESIS INHIBITION;
D O I：
10.1055/s-2006-959684
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Structure-related inhibitory effects on the prostaglandin synthesis in vitro have been detected among eight diterpenoids of the cembrane class (1-8). The 4,6-diols 1 and 2 are the most active of the cembranoids studied with IC50 values of 0. 36 and 0. 39 mM, respectively, as compared with an IC50 value of 1.4 for acetylsalicylic acid. Lower activities are found for cembranoids having undergone oxidation of/at the 11,12 double bond (5-8), while the 4-hydroxy-6-oxocembranoids 3 and 4 exhibit effects lower than those of 1 and 2 but higher than those of 5-8.
引用
收藏
页码：293 / 295
页数：3
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