This article offers a theoretical approach to a better understanding of the issue of the meaning of life, and proposes a methododology to configure various types of meaning, from an existential anthropological model. This model includes contributions of classical and contemporary philosophy and transcendental anthropology by L. Polo, and the proposal of meaning by V. Frankl Logotherapeutic School. The meaning of life model is a proposal and original contribution by the authors, which emerges from the correlation of anthropological and existential dimensions, constituted as axes that form the plane of the meaning of life from which emerge the types of meaning. These dimensions are the Anthropological Roots of Meaning and the Orientation Guidelines to the Meaning of Life. It is clear that the model presented here is capable of further advances both on a theoretical and methodological level and is not intended to answer the whole question of the manifestations of the meaning of human life.