SYNTHESIS OF PHOSPHOROTHIOATE ESTERS OF L-PHENYL-LACTIC ACID AS TRANSITION-STATE INHIBITORS OF CARBOXYPEPTIDASE-A

被引：4

作者：

HILL, JM

LOWE, G

机构：

[1] UNIV OXFORD,DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

[2] UNIV OXFORD,OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 16期

关键词：

D O I：

10.1039/p19950002001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diastereoisomeric phosphorothioate diesters and the phosphorothioate monoester df L-phenyl-lactic acid have been prepared and their inhibitory properties with carboxypeptidase A investigated. All the phosphorothioates have K-1-values in the micromolar range, suggesting that neither the stereochemistry nor additional negative charge on the phosphorothioate moiety has a major impact on binding.

引用

页码：2001 / 2007

页数：7

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