NEW TRIPEPTIDIC THROMBIN INHIBITORS - INFLUENCE OF P2 AND P3 RESIDUES ON ACTIVITY AND SELECTIVITY

被引：14
|
作者：
DENANTEUIL, G
GLOANEC, P
LILA, C
PORTEVIN, B
BOUDON, A
RUPIN, A
VERBEUREN, TJ
机构：
[1] INST RECH SERVIER,DIV MED CHEM,F-92150 SURESNES,FRANCE
[2] INST RECH SERVIER,DIV MOLEC MODELING,F-92150 SURESNES,FRANCE
[3] INST RECH SERVIER,DIV ANGIOL,F-92150 SURESNES,FRANCE
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 1995年 / 3卷 / 08期
关键词：
D O I：
10.1016/0968-0896(95)00107-R
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Structural variations of P2 and P3 residues in tripeptidic boroarginine thrombin inhibitors led to compounds with similar potency than reference compound DuP 714, but with enhanced selectivity for thrombin compared to plasmin.
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页码：1019 / 1024
页数：6
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