Molecular Pathogenesis and Targeted Therapies in Well-Differentiated Thyroid Carcinoma

被引：14
|
作者：
Kim, Jung Guk [1 ]
机构：
[1] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Endocrinol & Metab, 680 Gukchaebosang Ro, Daegu 700842, South Korea
来源：
ENDOCRINOLOGY AND METABOLISM | 2014年 / 29卷 / 03期
关键词：
Thyroid neoplasms; Targeted therapies;
D O I：
10.3803/EnM.2014.29.3.211
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Four proto-oncogenes commonly associated with well-differentiated thyroid carcinoma, rearranged during transfection (RET)/papillary thyroid cancer, BRAF, RAS, and PAX8/peroxisome proliferator activated receptor-., may carry diagnostic and prognostic significance. These oncogenes can be used to improve the diagnosis and management of well-differentiated thyroid carcinoma. Limited therapeutic options are available for patients with metastatic well-differentiated thyroid cancer, necessitating the development of novel therapies. Vascular endothelial growth factor (VEGF)-and RET-directed therapies such as sorafenib, motesanib, and sunitinib have been shown to be the most effective at inducing clinical responses and stabilizing the disease process. Further clinical trials of these therapeutic agents may soon change the management of thyroid cancer.
引用
收藏
页码：211 / 216
页数：6
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