OVEREXPRESSION OF LOW-DENSITY LIPOPROTEIN (LDL) RECEPTOR ELIMINATES LDL FROM PLASMA IN TRANSGENIC MICE

被引：107
|
作者：
HOFMANN, SL
RUSSELL, DW
BROWN, MS
GOLDSTEIN, JL
HAMMER, RE
机构：
[1] UNIV TEXAS,SW MED CTR DALLAS,HOWARD HUGHES MED INST,DALLAS,TX 75235
[2] UNIV TEXAS,SW MED CTR DALLAS,DEPT CELL BIOL,DALLAS,TX 75235
来源：
SCIENCE | 1988年 / 239卷 / 4845期
关键词：
D O I：
10.1126/science.3344433
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：1277 / 1281
页数：5
相关论文
共 50 条
  • [1] EFFECT OF CHEMICALLY MODIFIED LOW-DENSITY LIPOPROTEIN (LDL) ON LDL RECEPTOR SYNTHESIS
    LEUNG, AM
    IN VITRO-JOURNAL OF THE TISSUE CULTURE ASSOCIATION, 1980, 16 (03): : 246 - 246
  • [2] Overexpression of cholesterol 7α-hydroxylase (CYP7A) in mice lacking the low density lipoprotein (LDL) receptor gene -: LDL transport and plasma LDL concentrations are reduced
    Spady, DK
    Cuthbert, JA
    Willard, MN
    Meidell, RS
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (01) : 126 - 132
  • [3] REGULATION OF THE LOW-DENSITY LIPOPROTEIN (LDL) RECEPTOR BY CELL-DENSITY
    KENAGY, R
    BIERMAN, E
    SCHWARTZ, S
    JOURNAL OF CELL BIOLOGY, 1981, 91 (02): : A413 - A413
  • [4] INTERACTION OF LOW-DENSITY LIPOPROTEIN (LDL) FROM YOLK PLASMA WITH METHYL ORANGE
    NOWAK, CM
    POWRIE, WD
    FENNEMA, O
    JOURNAL OF FOOD SCIENCE, 1966, 31 (06) : 812 - &
  • [5] Low-density lipoprotein (LDL) oxidizability before and after LDL apheresis
    Donner, MG
    Parhofer, KG
    Richter, WO
    Schwandt, P
    METABOLISM-CLINICAL AND EXPERIMENTAL, 1999, 48 (07): : 881 - 886
  • [6] LOW-DENSITY LIPOPROTEIN (LDL) RECEPTORS AND THE REGULATION OF SERUM LDL LEVELS
    VERMEER, BJ
    NETHERLANDS JOURNAL OF MEDICINE, 1985, 28 (02): : 52 - 58
  • [7] STRUCTURE OF ATHEROGENIC LOW-DENSITY LIPOPROTEIN (LDL)
    TALL, A
    RUDEL, L
    SMALL, D
    ATKINSON, D
    CIRCULATION, 1978, 58 (04) : 170 - 170
  • [8] LOW-DENSITY LIPOPROTEIN (LDL) COMPLEXES WITH PROTAMINE
    SKRZYDLEWSKI, Z
    WOROWSKI, K
    BULLETIN DE L ACADEMIE POLONAISE DES SCIENCES-SERIE DES SCIENCES BIOLOGIQUES, 1976, 24 (04): : 201 - &
  • [9] MECHANISMS FOR THE REGULATION OF PLASMA LOW-DENSITY LIPOPROTEIN (LDL) IN NORMOLIPEMIC MAN
    HOWARD, BV
    EGUSA, G
    KESANIEMI, A
    GRUNDY, SM
    CLINICAL RESEARCH, 1985, 33 (01): : A10 - A10
  • [10] STIMULATION OF THE LOW-DENSITY LIPOPROTEIN (LDL) RECEPTOR BY PLATELET FACTOR (PF)
    CHAIT, A
    BIERMAN, EL
    ALBERS, JJ
    ROSS, R
    CIRCULATION, 1979, 60 (04) : 218 - 218
12345