GENOTOXICITY TESTING OF PIDOTIMOD IN-VITRO AND IN-VIVO

被引：0

作者：

ADAMS, K

ALLEN, JA

BROOKER, PC

HENDERSON, L

JONES, E

PROUDLOCK, RJ

MAILLAND, F

COPPI, G

机构：

[1] POLI IND CHIM SPA, RES CTR, DEPT SCI, I-20089 ROZZANO, ITALY

[2] HUNTINGDON RES CTR LTD, DEPT MUTAGENESIS & CELL BIOL, HUNTINGDON, ENGLAND

来源：

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH | 1994年 / 44-2卷 / 12A期

关键词：

BIOLOGICAL RESPONSE MODIFIERS; CAS; 121808-62-6; PGT/1A; PIDOTIMOD; GENOTOXICITY; MUTAGENICITY;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The mutagenic potential of pidotimod ((R)-3-[(S)-(5-oxo- -2-pyrrolidinyl)carbonyl]-thiazolidine-4-carboxylic acid, PGT/1A, CAS 121808-62-6) was assessed in a series of five assays designed to measure gene mutation, chromosomal damage and primary DNA damage. All tests were carried out in accordance with appropriate EEC and OECD Guidelines. No indications of mutagenic potential were observed in any of the assays.

引用

页码：1454 / 1459

页数：6

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