HUMAN GLIAL-CELL LINE-DERIVED NEUROTROPHIC FACTOR (GDNF) MAPS TO CHROMOSOME-5

被引：12
|
作者：
BERMINGHAM, N
HILLERMANN, R
GILMOUR, F
MARTIN, JE
FISHER, EMC
机构：
[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,ST MARYS HOSP,SCH MED,DEPT BIOCHEM & MOLEC GENET,LONDON W2 1PG,ENGLAND
[2] LONDON HOSP,COLL MED,DEPT HISTOPATHOL,LONDON E1 1BB,ENGLAND
来源：
HUMAN GENETICS | 1995年 / 96卷 / 06期
关键词：
D O I：
10.1007/BF00210297
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Neurotrophic factors are essential neurone survival promoting molecules that are often secreted and that bind to neuronal cell surface receptors. Glial cell line-derived neurotrophic factor, GDNF, is a potent neurotrophic factor that promotes the survival of dopaminergic neurones in cultures including embryonic neuronal cultures. We have mapped the gene encoding GDNF by two independent methods: using a cell hybrid panel and by fluorescent in situ hybridisation. We find GDNF lies on the short arm of human chromosome 5, at 5p13.1-p13.3.
引用
收藏
页码：671 / 673
页数：3
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