FUNCTIONAL-ACTIVITY OF MONOCLONAL AND MONOSPECIFIC ANTIBODIES DURING INTERACTION WITH ANTIGENIC SITES OF INFLUENZA-VIRUS HEMAGGLUTININ

被引：0
|
作者：
ISAYEVA, YI
ROVNOVA, ZI
PODCHERNYAYEVA, RY
机构：
来源：
VOPROSY VIRUSOLOGII | 1995年 / 40卷 / 01期
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中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Monospecific antibodies to three nonoverlapping sites of influenza A/Singapore/1/57 (H2N2) virus isolated from hyperimmune serum by specific adsorption were characterized by capacity to inhibit virus hemagglutination, immunochemically interact with hemagglutinin, and neutralize the virus (6-7.5 Ig). Monoclonal antibodies to the same virus hemagglutinin displayed an even higher activity than monospecific antibodies in serological and immunochemical tests and were characterized by a rather low (1.0-4.5 lg) or null activity in biological neutralization of the virus.
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页码：27 / 30
页数：4
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