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EFFECT OF DERMORPHIN ON BEHAVIOR AND HIPPOCAMPAL ELECTRICAL-ACTIVITY IN RABBITS

被引：6
|
作者：
FONTANI, G
VERGNANI, L
SALVADORI, S
VOGLINO, N
ALOISI, AM
PORTALUPPI, F
DEGLIUBERTI, EC
机构：
[1] UNIV FERRARA,INST INTERNAL MED,ENDOCRINOL SECT,VIA SAVONAROLA 9,I-44100 FERRARA,ITALY
[2] UNIV SIENA,INST HUMAN PHYSIOL,I-53100 SIENA,ITALY
[3] UNIV SIENA,DEPT PHARMACEUT SCI,I-53100 SIENA,ITALY
来源：
LIFE SCIENCES | 1993年 / 52卷 / 03期
关键词：
D O I：
10.1016/0024-3205(93)90224-Q
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Dermorphin, a naturally occurring heptapeptide that selectively binds to mu-opioid receptors, was injected intravenously 0.4 mg/kg in male rabbits. Eight days before injection the spontaneous behavior of the animals was observed in a neutral environment in the absence of extemal stimuli. At the same time, hippocampal EEG was recorded by telemetry. After dermorphin injection, the same experimental procedure was repeated. Behavior showed a strong increase in quiet immobility and a concomitant reduction in voluntary activities as compared to control periods. Treatment did not affect either the pattern or the frequency of hippocampal electrical activity.
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页码：323 / 328
页数：6
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