SWINE-RECONSTITUTED SCID MICE AS A MODEL FOR AFRICAN SWINE FEVER VIRUS-INFECTION

被引：6
|
作者：
REVILLA, Y [1 ]
PENA, L [1 ]
MAMPASO, F [1 ]
VINUELA, E [1 ]
MARTINEZALONSO, C [1 ]
机构：
[1] CTR ESPECIAL RAMON & CAJAL, E-28034 MADRID, SPAIN
来源：
JOURNAL OF GENERAL VIROLOGY | 1994年 / 75卷
关键词：
D O I：
10.1099/0022-1317-75-8-1983
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Injection of swine peripheral blood mononuclear cells into mice with severe combined immunodeficiency (SCID), resulted in the stable long-term establishment of a functional swine immune system (SCTD-sw). Swine immunoglobulins were present in the serum of SCID-sw mice and swine cells were detected in the blood as well as in lymph nodes and spleen using monoclonal antibodies raised against cell subpopulations. Swine lymphocytes from reconstituted SCID mice responded in vitro to specific antigens or mitogens. When SCID-sw mice were challenged with African swine fever (ASF) virus, ASF virus-infected cells were detected in blood and spleen, and antiviral antibodies and virus-specific T cells were generated.
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页码：1983 / 1988
页数：6
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