NONANIMAL ALTERNATIVE TOXICITY TESTS FOR DETERGENTS - GENUINE REPLACEMENTS OR MERE PRESCREENS

被引：0

作者：

BALLS, M ^{[1
]}

READER, S ^{[1
]}

ATKINSON, K ^{[1
]}

TARRANT, J ^{[1
]}

CLOTHIER, R ^{[1
]}

机构：

[1] UNIV NOTTINGHAM HOSP,QUEENS MED CTR,SCH MED,DEPT HUMAN MORPHOL,NOTTINGHAM NG7 2UH,ENGLAND

来源：

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY | 1991年 / 50卷 / 03期

关键词：

SURFACTANTS; TOXICITY TESTS; REPLACEMENT ALTERNATIVES; EYE IRRITANCY;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Non-animal toxicity tests and testing strategies for use in identifying the potential toxic hazard of chemicals and products, and in providing information for use in risk and safety assessment, are in the course of development, validation and evaluation. Possible replacement alternatives to the rabbit Draize eye irritancy test are discussed, and results obtained for two in-vitro tests developed by FRAME (the kenacid blue test and the neutral red release test), applied to 19 surfactants and 32 formulations, are discussed. It is concluded that there are now legal and moral requirements that relevant and reliable non-animal tests should be developed and accepted for use whenever possible.

引用

页码：423 / 433

页数：11

共 24 条

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