ABSOLUTE-CONFIGURATION OF 7,12-DIMETHYLBENZ[A]ANTHRACENE-DNA ADDUCTS IN MOUSE EPIDERMIS

被引：19
|
作者：
VERICAT, JA [1 ]
CHENG, SC [1 ]
DIPPLE, A [1 ]
机构：
[1] NCI,FREDERICK CANC RES & DEV CTR,CHEM CARCINOGENESIS LAB,ABL BASIC RES PROGRAM,FREDERICK,MD 21702
来源：
CANCER LETTERS | 1991年 / 57卷 / 03期
关键词：
P-32-POSTLABELING; 7,12-DIMETHYLBENZ[A]ANTHRACENE; DNA ADDUCTS; MOUSE EPIDERMIS; STEREOCHEMISTRY;
D O I：
10.1016/0304-3835(91)90163-C
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
P-32-Postlabeling was used to monitor the formation of DMBA-DNA adducts in mouse epidermis from each enantiomer of the trans 3,4-dihydrodiol. It was shown that the (4R,3R)-dihydrodiol is converted to the anti (4R,3S)-dihydrodiol (2S,1R)-epoxide which reacts with deoxyguanosine and deoxyadenosine residues in epidermal DNA to yield two of the major adducts formed when DMBA itself binds to epidermal DNA. The third major DMBA-derived adduct with deoxyadenosine residues was shown to arise from the (4S,3R)-dihydrodiol through the intermediacy of the syn (4S,3R)-dihydrodiol (2S,1R)-epoxide.
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页码：237 / 242
页数：6
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