SYNTHESIS OF ENANTIOPURE (S)-ALPHA-HYDROXY CARBOXANILIDES FROM (S)-ALPHA-AMINO ACIDS

被引：0

作者：

GIRRESER, U

NOE, CR

机构：

来源：

SYNTHESIS-STUTTGART | 1995年 / 10期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Hydroxy carboxanilides 3a-c were obtained without racemization in a synthetically simple way starting from the corresponding alpha-amino acids by diazotization and subsequent treatment of the sodium alpha-hydroxy carboxylates with anilinium chloride in moderate yields. The enantiopurity of 3a-c was easily determined by H-1 NMR spectroscopy of the diastereomeric O,O-acetals 5/6a-c derived from exo-lactol 4.

引用

页码：1223 / 1224

页数：2

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