THE EFFECT OF VOLUME EXPANSION ON ATRIAL-NATRIURETIC-PEPTIDE AND CYCLIC GUANOSINE-MONOPHOSPHATE LEVELS IN YOUNG AND AGED SUBJECTS

被引：27

作者：

TAN, ACITL

HOEFNAGELS, WHL

SWINKELS, LMJW

KLOPPENBORG, PWC

BENRAAD, TJ

机构：

[1] CATHOLIC UNIV NIJMEGEN,ST RADBOUD HOSP,DEPT MED,DIV CLIN ENDOCRINOL,6500 HB NIJMEGEN,NETHERLANDS

[2] CATHOLIC UNIV NIJMEGEN,ST RADBOUD HOSP,DC,6500 HB NIJMEGEN,NETHERLANDS

来源：

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY | 1990年 / 38卷 / 11期

关键词：

D O I：

10.1111/j.1532-5415.1990.tb01502.x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The relationship between atrial natriuretic peptide (ANP) and age was studied. In elderly subjects (65 to 84 years) higher basal ANP levels were found as compared with those found in young subjects (21 to 23 years). Volume loading (750 mL 0.9% NaCl in 60 minutes) increased ANP levels only in the aged group, and plasma renin activity decreased only in the young subjects. Plasma aldosterone levels did not change. Basal cyclic guanosine monophosphate values did not differ in either group, and rose to a similar extent during volume loading. High pressure liquid chromatography analysis did not suggest different molecular forms of immunoreactive ANP in elderly subjects. The main circulating component both basal and after stimulation corresponds to the (99–126)hANP form. © 1990 The American Geriatrics Society

引用

页码：1215 / 1219

页数：5

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