NCAM-ANTIBODIES MODULATE INDUCTION OF LONG-TERM POTENTIATION IN RAT HIPPOCAMPAL CA1

被引：151

作者：

RONN, LCB ^{[1
]}

BOCK, E ^{[1
]}

LINNEMANN, D ^{[1
]}

JAHNSEN, H ^{[1
]}

机构：

[1] UNIV COPENHAGEN,PANUM INST,DIV NEUROPHYSIOL,DK-2200 COPENHAGEN N,DENMARK

来源：

BRAIN RESEARCH | 1995年 / 677卷 / 01期

关键词：

LONG-TERM POTENTIATION; NEURAL CELL ADHESION MOLECULE; NCAM; HIPPOCAMPUS; CA1; SYNAPTIC PLASTICITY;

D O I：

10.1016/0006-8993(95)00147-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neural cell adhesion molecule (NCAM) probably plays a role in neural plasticity in the adult vertebrate brain. We here present evidence that NCAM may be involved in long-term potentiation (LTP) in the CA1-region of rat hippocampal slices. It is shown that local application of antibodies against NCAM inhibits subsequent LTP-induction. Thus NCAM may be directly involved in the initial phase of LTP-induction. These results have important implications for the possible involvement of NCAM in learning and memory.

引用

页码：145 / 151

页数：7

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