GALLOPAMIL AND CHANGES OF ADENOSINE-DIPHOSPHATE-INDUCED AND COLLAGEN-INDUCED PLATELET-AGGREGATION

被引：0

作者：

KOLTRINGER, P

LANGSTEGER, W

LIND, P

PIERER, G

REISECKER, F

EBER, O

机构：

[1] KRANKENHAUSES BARMHERZIGEN BRUDER GRAZ EGGENBERG,NEUROL PSYCHIAT ABT,BERGSTR 27,A-8021 GRAZ,AUSTRIA

[2] KRANKENHAUS BARMHERZIGEN BRUDER GRAZ EGGENBERG,INTERNE MED ABT,A-8021 GRAZ,AUSTRIA

[3] KRANKENHAUS BARMHERZIGEN BRUDER GRAZ EGGENBERG,NEUROL ABT,A-8021 GRAZ,AUSTRIA

[4] GRAZ UNIV,CHIRURG KLIN,DEPT PLAST CHIRURG,A-8010 GRAZ,AUSTRIA

来源：

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1991年 / 41-2卷 / 08期

关键词：

CALCIUM ANTAGONISTS; CAS; 16662-47-8; GALLOPAMIL; INHIBITION OF PLATELET AGGREGATION; CLINICAL STUDIES; PLATELET AGGREGATION;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In blood samples of 12 healthy volunteers (5 female, 7 male) the influence of Gallopamil (Procorum(R), CAS 16662-47-8) on the adenosin-diphosphate- (ADP-) and collagen-induced platelet aggregation was studied. Measurements in platelet rich plasma after induction with 1-mu-mol ADP and 0.5-mu-g/ml collagen with gallopamil were performed. After incubation mit 250-mu-mol gallopamil a second test was carried out. The parameters were compared with the U-test. After application of 250-mu-mol gallopamil a significant reduction of ADP- and collagen-induced platelet aggregation could be observed. This is a sign for a protective effect of gallopamil in atherosclerotic disorders due to its calcium-channel blocking property.

引用

页码：786 / 788

页数：3

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