DETECTION OF HUMAN-ANTIBODY AGAINST THE HUMAN PAPILLOMAVIRUS TYPE-16 E7 PROTEIN

被引：5
|
作者：
HASHIDO, M
KANDA, T
ZANMA, S
WATANABE, S
KOMIYAMA, N
YOSHIKAWA, H
YAMAGUCHI, N
KAWANA, T
YOSHIIKE, K
机构：
[1] NATL INST HLTH,DEPT ENTEROVIRUSES,SHINAGAWA KU,TOKYO 141,JAPAN
[2] CHUGAI PHARMACEUT CO LTD,CTR DIAGNOST,APPL RES LABS,TOSHIMA KU,TOKYO 171,JAPAN
[3] UNIV TOKYO,DEPT OBSTET & GYNECOL,BUNKYO KU,TOKYO 113,JAPAN
[4] TOKYO UNIV,BRANCH HOSP,DEPT OBSTET & GYNECOL,BUNKYO KU,TOKYO 112,JAPAN
来源：
JAPANESE JOURNAL OF CANCER RESEARCH | 1991年 / 82卷 / 12期
关键词：
HPV; 16; E7; HUMAN ANTI-E7 ANTIBODY; CERVICAL CANCER;
D O I：
10.1111/j.1349-7006.1991.tb01813.x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We examined 500 human sera for the presence of antibody against the human papillomavirus type 16 E7 protein by enzyme-linked immunosorbent assay with bacterially expressed fusion protein lac-E7, and by radioimmunoprecipitation and immunofluorescence assays with the E7 protein expressed in monkey COS-1 cells. The anti-E7 antibody was detectable in 6 out of 54 cases of cervical carcinoma, but in none of the others, including patients with other gynecologic cancers, those with sexually transmitted diseases, and healthy adults. The data indicate that expression of the E7 protein is closely related to cervical carcinoma.
引用
收藏
页码：1406 / 1412
页数：7
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