A LIQUID-CHROMATOGRAPHIC METHOD FOR DETERMINATION OF THEOPHYLLINE IN SERUM AND CAPILLARY BLOOD - A COMPARISON

被引：0
|
作者：
GARTZKE, J [1 ]
JAGER, H [1 ]
VINS, I [1 ]
机构：
[1] TESSEK LTD, CS-11000 PRAGUE 1, CZECHOSLOVAKIA
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1991年 / 9卷 / 10-12期
关键词：
THEOPHYLLINE THERAPEUTIC DRUG MONITORING; CAPILLARY BLOOD; SERUM; HPLC; SOLID PHASE EXTRACTION;
D O I：
10.1016/0731-7085(91)80034-7
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A simple, fast and reliable liquid chromatographic method for the determination of theophylline in serum and capillary blood after a solid phase extraction is described for therapeutic drug monitoring. The employment of capillary blood permits the determination of an individual drug profile and other pharmacokinetic studies in neonates and infants. There were no differences in venous- and capillary-blood levels but these values compared poorly with those in serum. An adjustment of the results by correction of the different volumes of serum and blood by haematocrit was unsuccessful. Differences in the binding of theophylline to erythrocytes could be an explanation for the differences in serum at blood levels of theophylline.
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页码：981 / 984
页数：4
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