ACTH FRAGMENTS REVERSE EXPERIMENTAL HEMORRHAGIC-SHOCK IN RATS

被引：0
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作者：
COPPI, G
FALCONE, A
机构：
来源：
DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH | 1992年 / 18卷 / 05期
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R9 [药学];
学科分类号：
1007 ;
摘要：
Hypovolemic shock was produced in rats by withdrawing about 50% of estimated total blood volume. Following mean arterial pressure stabilization in the range of 25-27 mmHg, the rats were given intravenous ACTH (1 - 4) (4 - 9) (4 - 10) (5 - 10) (1 - 10) in comparison with ACTH (1 - 24). The ACTH fragments, administered within 5min after shock induction, promptly and dose-dependently improved mean arterial pressure and survival of rats; the ACTH (1 - 10) showed an activity similar to that of ACTH (1 - 24) whereas the other fragments were less active.
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页码：173 / 177
页数：5
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