CHIRAL SEPARATIONS OF BASIC AND ACIDIC COMPOUNDS IN MODIFIED CAPILLARIES USING CYCLODEXTRIN-MODIFIED CAPILLARY ZONE ELECTROPHORESIS

被引：47
|
作者：
BELDER, D [1 ]
SCHOMBURG, G [1 ]
机构：
[1] MAX PLANCK INST KOHLENFORSCH,DEPT CHROMAT,W-4330 MULHEIM,GERMANY
来源：
JOURNAL OF CHROMATOGRAPHY A | 1994年 / 666卷 / 1-2期
关键词：
D O I：
10.1016/0021-9673(94)80395-1
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Chiral separations of basic drugs and organic acids can be achieved using cyclodextrins or cyclodextrin derivatives as chiral selectors in surface-modified capillaries. The influence of temperature and selector concentration on separation performance was investigated in specially modified capillaries. Separations of basic compounds at acidic pH were performed in capillaries modified by either dynamic or permanent coating by adsorption of non-ionic hydroxylic polymers. Separations of acidic compounds could be significantly improved by use of thermally immobilized poly(vinyl alcohol) or adsorbed cationic polymers as surface coatings. The influence of non-ionic and cationic coatings on separations of acidic compounds was compared with regard to resolution, separation efficiency and analysis time.
引用
收藏
页码：351 / 365
页数：15
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