STUDIES DIRECTED TOWARDS THE TOTAL SYNTHESIS OF (+/-)-HIMBACINE

被引：16
|
作者：
DEBAECKE, G [1 ]
DECLERCQ, PJ [1 ]
机构：
[1] STATE UNIV GHENT,DEPT ORGAN CHEM,B-9000 GHENT,BELGIUM
来源：
TETRAHEDRON LETTERS | 1995年 / 36卷 / 41期
关键词：
D O I：
10.1016/0040-4039(95)01520-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of aldehyde 11a is reported based upon the intramolecular Diels-Alder reaction of triene 10, the butenolide-diene part of which was obtained in one step via the condensation of the enolate derived from the (Z)-enoate ester 5 with 2-acetoxypropanal. Aldehyde 11a possesses the correct stereochemistry of the tricyclic part of himbacine, an important muscarine receptor antagonist.
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收藏
页码：7515 / 7518
页数：4
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