Mixtures of chlorimuron and 2,4-DB were additive with respect to crop injury and were either additive or slightly antagonistic with respect to weed control in greenhouse experiments. Absorption and translocation of C-14 following application of C-14-chlorimuron and C-14-2,4-DB were not affected by the presence of the other unlabeled herbicide, except in Florida beggarweed and peanut where 2,4-DB affected distribution of C-14-chlorimuron in the treated leaf. In field studies, maximum efficacy was obtained with mixtures of chlorimuron plus 2,4-DB applied 7 or 9 wk after planting. Florida beggarweed control was greatest with chlorimuron or chlorimuron mixtures while the addition of 2,4-DB to chlorimuron improved morning-glory and sicklepod control. At 9 and 11 wk after planting, addition of 2,4-DB to chlorimuron controlled Florida beggarweed better than chlorimuron alone. Peanut yields were increased by the addition of 2,4-DB at later applications.